Protein Modification Reagents
Medchemexpress LLC Azide-PEG5-tos | 236754-49-7 | 98.5% | 417.48 g·mol⁻¹ | C17H27N3O7S | 1 G
Azide-PEG5-Tos is a cleavable 5-unit polyethylene glycol (PEG) linker bearing an azide functional group and a tosyl terminus, designed for bioconjugation and ADC linker synthesis. The PEG spacer increases aqueous solubility and the azide enables click chemistry reactions such as CuAAC and SPAAC.
- Cleavable 5-unit PEG spacer increases aqueous solubility.
- Azide functional group enables CuAAC and SPAAC click reactions.
- Tosyl terminus acts as a leaving group for nucleophilic substitution.
- Available in multiple pack sizes, including 1 G.
- High purity (98.5%) and characterized molecular weight 417.48 g·mol⁻¹.
Medchemexpress LLC Dbco-peg4-val-cit-pab-mmaf | 2244602-23-9 | 98.7% | 1672.01 g/mol | C88H126N12O20 | 5 MG
DBCO-PEG4-Val-Cit-PAB-MMAF is a cleavable linker-payload conjugate used for antibody-drug conjugate synthesis and bioconjugation. The construct combines a DBCO bioorthogonal handle, a PEG4 spacer, a cathepsin-cleavable valine-citrulline dipeptide with a PAB self-immolative spacer, and an MMAF cytotoxic payload. Analytical documentation and handling instructions are available.
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC) via DBCO for click chemistry.
- Peg4 spacer increases hydrophilicity and reduces aggregation.
- Val-Cit dipeptide is cleavable by cathepsin enzymes for controlled payload release.
- PAB self-immolative spacer allows rapid payload liberation after cleavage.
- Contains MMAF, a tubulin inhibitor payload for ADC applications.
- High reported purity with supporting analytical data and safety documentation.
Medchemexpress LLC Biotin-PEG4-TFP ester | 2985664-57-9 | MFCD27952880 | 98.2% | C27H37F4N3O8S | 10MG
Biotin-PEG4-TFP ester is a biotinylated PEG4 spacer terminated with a tetrafluorophenyl (TFP) activated ester, formulated for conjugation to primary amines in proteins, peptides, or small molecules. It enables rapid formation of stable amide bonds while providing a hydrophilic linker that reduces steric hindrance and improves solubility. The TFP activated ester offers greater hydrolytic stability than many NHS esters, supporting cleaner bioconjugation and linker assembly workflows.
- Activated TFP ester for efficient coupling to primary amines.
- Biotin tag for affinity capture and detection.
- PEG4 spacer improves solubility and reduces steric hindrance.
- Greater hydrolytic stability than many NHS esters, enabling cleaner conjugations.
- Suitable for protein, peptide, and small-molecule conjugation applications.
(=O)OCCNC(=O)OCCOCC(=O)NCc1ccc(cc1F)B(O)O)OC(=O)CCCCCCCCCCCCCCCCC | 100mg | 718091659](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502474728.jpg-250.jpg)
eMolecules DSPE-PEG-Boronate, MW 3,400 | Broadpharm |1045.130 | C53H95BFN2O14P | 98.000 | CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCCNC(=O)OCCOCC(=O)NCc1ccc(cc1F)B(O)O)OC(=O)CCCCCCCCCCCCCCCCC | 100mg | 718091659
DSPE-PEG-Boronate, MW 3,400 | Broadpharm |1045.130 | C53H95BFN2O14P | 98.000 | CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCCNC(=O)OCCOCC(=O)NCc1ccc(cc1F)B(O)O)OC(=O)CCCCCCCCCCCCCCCCC | 100mg | 718091659
Enzo Life Sciences Gefitinib-based PROTAC 3 (1mg). CAS: 2230821-27-7
Gefitinib-based PROTAC 3 is targeting on EGFR, consisting of Gefitinib as the warhead linked to VHL-recruiting ligand. Purity: ≥99%. Solubility: Soluble in DMSO (75 mg/mL). Insoluble in water. Long Term Storage: -20°C.
eMolecules 134978-99-7 | Amino-PEG3-CH2CO2H | Broadpharm | MFCD24479841 | 207.226 | C8H17NO5 | 98.000 | NCCOCCOCCOCC(O)=O | 1g | 347153871
Amino-PEG3-CH2CO2H | Broadpharm | 134978-99-7 | MFCD24479841 | 207.226 | C8H17NO5 | 98.000 | NCCOCCOCCOCC(O)=O | 1g | 347153871
STA Pharmaceutical Fmoc-NH-PEG5-CH2COOH | 50 g | CAS 635287-26-2 | InChIKey LNIFRTLAPAPKAG-UHFFFAOYSA-N
Fmoc-NH-PEG5-CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 50 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 635287-26-2
- MDL: No data
- InChIKey: LNIFRTLAPAPKAG-UHFFFAOYSA-N
- Molecular Weight: 517.575
- Molecular Formula: C27H35NO9
- Purity: ≥95%
- Container Type: 250 mL HDPE
- Pack Size: 50 g
- Net Weight: 50 g
- Gross Weight: 89.8 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19-hexaoxa-4-azahenicosan-21-oic acid
- SMILES: O=C(COCCOCCOCCOCCOCCNC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)O
Medchemexpress LLC HOOC-PEG-SH MW 5000 5mg
HOOC-PEG-SH (MW 5000) (HOOC-PEG-Thiol (MW 5000)) is a reactive thiol PEG derivative with a terminal carboxyl group The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond The PEG linkage between the thiol and carboxyl groups has good water solubility flexible linker distance and higher stability[1]
Medchemexpress LLC 4-((S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)-5-ur... | 2722697-82-5 | MFCD00867744 | 99.9% | 1126.65 g·mol-1 | C55H68ClN11O13 | 5 MG
MC-VC-PABC-amide-PEG1-CH2-CC-885 is a neoDegrader-linker conjugate that couples a GSPT1-targeting degrader payload to a cleavable linker via a short PEG spacer. It is supplied as a research reagent for biochemical and cell-based studies of targeted protein degradation and assay development.
- NeoDegrader-linker conjugate designed for targeted protein degradation studies.
- GSPT1-targeting degrader payload for selective biological activity.
- Cleavable valine-citrulline PABC-type linker enabling intracellular payload release.
- Short PEG spacer improves solubility and linker flexibility.
- High reported purity suitable for research applications.
- Soluble in DMSO; may require sonication, use anhydrous DMSO for best results.
- Store at -20°C, protect from light; in solvent store at -80°C for long-term storage.
Medchemexpress LLC Acid-C2-PEG4-C2-NHS ester | 1343476-41-4 | 98.0% | 25 MG
Acid-C2-PEG4-C2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- One ligand for an E3 ubiquitin ligase and the other for the target protein
- Leverages the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Mal-PEG4-propargyl | 1262681-30-0 | 99.68% | 311.33 | 100 MG
Mal-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. For research use only.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an Alkyne group
- Can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
Medchemexpress LLC DiSulfo-Cy5 alkyne | 1617497-19-4 | C35H40N3NaO7S2 | 5 MG
DiSulfo-Cy5 alkyne is a fluorescent dye utilized as a click chemistry reagent. This compound is provided as a solid with high purity, suitable for various research applications. It is important to store it properly to maintain its stability and effectiveness.
- Molecular weight: 701.83
- Purity: 98.97%
- Appearance: Solid
- Color: Brown to dark brown
- In vitro solubility: DMSO 50 mg/mL (71.24 mM)
- Storage conditions: -20°C, sealed, away from moisture and light
- Storage in solvent: -80°C for 6 months; -20°C for 1 month
Medchemexpress LLC DSPE-PEG-Maleimide | 1612754-08-1 | 100.0% | 2000 | 50 MG
DSPE-PEG-Maleimide (MW 2000) is a functional lipid component and a thiol-reactive crosslinker. It undergoes Michael addition with the thiol groups of thiolated or cyclic RGD peptides to form stable thioether bonds and DSPE-PEG (2000)-RGD. This product is applicable to research on drug delivery.
- Functional lipid component
- Thiol-reactive crosslinker
- Undergoes Michael addition with thiol groups
- Forms stable thioether bonds
- Forms DSPE-PEG (2000)-RGD with thiolated or cyclic RGD peptides
- Applicable to research on drug delivery
eMolecules 9004-74-4 | m-PEG11-alcohol | Broadpharm | MFCD06201004 | 516.625 | C23H48O12 | 98.000 | COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO | 10g | 550803933
m-PEG11-alcohol | Broadpharm | 9004-74-4 | MFCD06201004 | 516.625 | C23H48O12 | 98.000 | COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO | 10g | 550803933